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This study was undertaken for the clinical analysis and evaluation of the women with trophoblastic tumors who were admitted and treated at the Yonsei University Medical Center from Jan. 1,1961 to June 30, 1972. A total of 187 cases were seen with the following distribution: Hydatidiform mole 94, chorioadenoma destruens 17, and choriocarcinoma 76. The following features were the results of this study: 1. Hydatidiform mole occurred approximately once in every 186 pregnancies and 161 deliveries, chorioadenoma destruens once in every 1028 pregnancies and 889 deliveries, choriocarcinoma once in every 230 pregnancies and 199 deliveries, respectively. 2. While the rate of normal intrauterine pregnancy declines markedly after the age of 40, the occurrence of the trophoblastic tumor after this age become remarkably increased. It was noteworthy that the incidence of choriocarcinoma increased in proportion to the gravidity. 3. Among the patients with choriocarcinoma, 71 per cent of patient had lung metastasis, 21 per cent vagina, 8 per cent brain, and 4 per cent G-I tract. 4. In cases of choriocarcinoma, 33 per cent of cases occur after hydatidiform mole, 30 per cent after term pregnancies, 30 per cent after abortion. 5. Forty seven per cent of the patient with hydatidiform mole were managed by D & E, hysterectomy was done in 41 per cent of the patient with chorioadenoma destruens, and 53 per cent of the patient with choriocarcinoma were managed by chemotherapy with Methotrexate alone or Methotrexate and Actinomycin-D. 6. In the patient with chorioadenoma destruens, remission rate was 76 per cent. In patients with choriocarcinoma, remission rate was 51 per cent, mortality rate was 26 per cent and recurrence rate was 12 per cent respectively. In the cases of choriocarcinoma the earlier the treatment, the better the result. Among the patient with remission after chemotherapy, most of them had at least 3 kurs of therpapy, and the patient with multiple metastasis showed very poor remission rate compared with those without metastasis.
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